Why Is Sympathetic Nerve Activity to the Heart Increased in Heart Failure?

Grant number: 509204 | Funding period: 2008 - 2010

Completed

Abstract

Heart failure is a disabling and deadly syndrome that has reached epidemic proportions in western populations. In heart failure, the activity of the sympathetic nerves to the heart is dramatically increased, leading to development of arrhythmias and sudden death. Using our unique model of heart failure, in which we directly record cardiac sympathetic nerve activity, we aim to determine the mechanisms in the brain that cause this large, detrimental increase in nerve activity.

Related publications (9)

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Central exogenous nitric oxide decreases cardiac sympathetic drive and improves baroreflex control of heart rate in ovine heart failure

R Ramchandra, SG Hood, CN May

2014-01-01

Heart failure (HF) is associated with increased cardiac and renal sympathetic drive, which are both independent predictors of poor..

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Cardiac sympathoexcitation in heart failure

CN May, ST Yao, LC Booth, R Ramchandra

2013-04-01

Heart failure (HF) is a serious debilitating condition with poor survival rates and an increasing level of prevalence. The excessi..

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Central angiotensin type 1 receptor blockade decreases cardiac but not renal sympathetic nerve activity in heart failure

R Ramchandra, SG Hood, AMD Watson, AM Allen, CN May

2012-03-01

In heart failure (HF), cardiac sympathetic nerve activity (SNA; CSNA) is increased, which has detrimental effects on the heart and..

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Central Angiotensin Type 1 Receptor Blockade Decreases Cardiac But Not Renal Sympathetic Nerve Activity in Heart Failure

R Ramchandra, SG Hood, AM Watson, AM Allen, CN May

2012-01-01

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Hypertonic sodium resuscitation after hemorrhage improves hemodynamic function by stimulating cardiac, but not renal, sympathetic nerve activity

R Frithiof, R Ramchandra, SG Hood, CN May

2011-02-01

Small volume hypertonic saline resuscitation can be beneficial for treating hemorrhagic shock, but the mechanism remains poorly de..

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Response of cardiac sympathetic nerve activity to intravenous irbesartan in heart failure

R Ramchandra, AMD Watson, SG Hood, CN May

2010-04-01

To determine the effect of irbesartan treatment on resting levels and arterial baroreflex control of cardiac sympathetic nerve act..

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Specific control of sympathetic nerve activity to the mammalian heart and kidney

CN May, R Frithiof, SG Hood, RM McAllen, MJ McKinley, R Ramchandra

2010-01-01

There is a large body of evidence indicating that sympathetic nerves to individual organs are specifically controlled, but only fe..

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Discharge properties of cardiac and renal sympathetic nerves and their impaired responses to changes in blood volume in heart failure

R Ramchandra, SG Hood, R Frithiof, CN May

2009-09-01

Sympathetic nerve activity (SNA) consists of discharges that vary in amplitude and frequency, reflecting the level of recruitment ..

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Basis for the preferential activation of cardiac sympathetic nerve activity in heart failure

R Ramchandra, SG Hood, DA Denton, RL Woods, MJ McKinley, RM McAllen, CN May

2009-01-20

In heart failure (HF) , sympathetic nerve activity is increased. Measurements in HF patients of cardiac norepinephrine spillover, ..

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